The Expression and Relationship of AKT and ERK1/2 Proteins in Hypopharyngeal Squamous Cell Carcinoma
10.3969/j.issn.0253-9896.2014.03.020
- VernacularTitle:AKT、ERK1/2在下咽鳞状细胞癌中的表达及其相关性
- Author:
Ke YANG
;
Jingcheng GU
- Publication Type:Journal Article
- Keywords:
carcinoma,squamous cell;
hypopharynx;
hypopharyngeal neoplasms;
immunohistochemistry;
AKT;
ERK1/2
- From:
Tianjin Medical Journal
2014;(3):257-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of AKT and ERK1/2 proteins in hypopharyngeal squamous cell carcinoma and normal hypopharyngeal mucosa. Methods The expressions of AKT and ERK1/2 proteins were exam-ined by immunohistochemical S-P technique in 60 patients with hypopharyngeal squamous cell carcinoma and 15 cases of normal hypopharyngeal mucosa . The relationship between expressions of AKT and ERK1/2 proteins and clinical pathologi-cal feathers was analyzed. Results The positive rates of the expressions of AKT and ERK1/2 were 78.3% (47/60) and 66.7%(40/60) in 60 cases of hypopharyngeal squamous cell carcinoma, which were significantly higher than those in 15 cas-es of normal hypopharyngeal mucosa [13.3%(2/15) and 6.7%(1/15), P<0.05]. The lower the degree of differentiation, the later the clinical stage, the higher the positive expression rates of AKT and ERK1/2. There were significantly higher expres-sions of AKT and ERK1/2 in patients with lymph node metastasis than those of patients without lymph node metastasis (P<0.05 or P<0.01). There was a positive correlation between expression levels of AKT and ERK1/2 (rs=0.400,P<0.05). Con-clusion There were higher expression levels of AKT and ERK1/2 in hypopharyngeal squamous cell carcinoma. The activa-tion of AKT and ERK1/2 proteins promotes hypopharyngeal occurrence, development and metastasis.
