Research progress of multiple myeloma related microRNA
10.3760/cma.j.issn.1009-9921.2014.07.019
- VernacularTitle:多发性骨髓瘤相关微小RNA的研究进展
- Author:
Cuirong XIAO
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
microRNA
- From:
Journal of Leukemia & Lymphoma
2014;23(7):442-445
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA) is a kind of non-coding small RNA that regulate gene expression at a post-transcriptional level by inhibiting the translation or direct degradation of specific target mRNA.Lots of studies have shown that deregulation of miRNA expression is associated with multisystem tumor.Studies on multiple myeloma (MM) have found that aberrant expression of miRNA regulate MM-cellular processes including cell proliferation,differentiation,apoptosis and drug-resistance.And they can act as diagnostic marker for MM.Some of the miRNA may even function as effective therapeutic targets.This paper reviewed the research progress of the aberrant expression of MM related miRNA in the diagnosis,pathogenesis,drug resistance of MM and its potential application as therapeutic targets.
