Exosomes and cancer immunotherapy
10.3760/cma.j.issn.1009-9921.2012.06.017
- VernacularTitle:胞外体与肿瘤免疫治疗
- Author:
Jing SUN
- Publication Type:Journal Article
- Keywords:
Dendritc cell;
Tumor cell;
Exosomes;
Cancer immunoterapy
- From:Journal of Leukemia & Lymphoma
2012;21(6):373-375
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are endosome-derived vesicles (40-100 nm) formed during the formation of multi-vesicular bodies(MVBs),which contains plasma membrane,membrane protein and functional signaling protein.The variety of proteins depends on the origin of EXO and thus imparts distinct biological function.Exosomes derived from antigen-presenting cells (APC),such as dendritic cells,and tumor cells may play an important role in immunological regulation and cancer immunotherapy.The present review summarizes the recent studies of EXO-related biological function.
