Relationship of CD_4~+ CD_(25)~+ regulatory T cells and acute myeloid leukemia

VernacularTitle:CD_4~+ CD_(25)~+调节性T细胞与急性髓细胞白血病关系的研究
Author: Shengneng TAO ; Huiping WANG ; Yuanyuan SHEN ; Juan LU ; Yiming ZHAO ; Zhimin ZHAI
Publication Type:Journal Article
Keywords: Leukemia; CD_4~+ CD_(25)~+ regulatory T cells; CD_(127)
From: Journal of Leukemia & Lymphoma 2009;18(11):654-656
CountryChina
Language:Chinese
Abstract: Objective To investigate the proportion of CD_4~+ CD_(25)~+ Tregs in the peripheral blood of the patients suffering from acute myeloid leukemia (AML) with or without chemotherapy and clinical significance.Methods The flow cytometry was used to evaluate the proportion of CD_4~+ CD_(25)~+ CD_(127)~(low) T cells in the peripheral blood of the patients with primary AML group (group A), AML who achieved complete remission over 3 years (group C) or less than 3 years(group B) and the healthy donors. Results The percentages of CD_4~+ CD_(25)~+ Tregs of group A and B was significantly higher than that of control group (P <0.05); but not significantly defferent among the group C and control group (P >0.05). The percentages of CD_4~+ CD_(25)~+ Tregs of group A was significantly higher than that of group B and C. Conclusion These results suggested that CD_4~+ CD_(25)~+ Tregs played an important role in acute myeloid leukemia.