Clinical study of 64 patients with invasive fungal infection in hemopathic neoplasms treated with caspofungin

VernacularTitle:卡泊芬净治疗血液肿瘤合并侵袭性真菌感染64例
Author: Lixiang LIU ; Fanyi MENG ; Fen HUANG ; Dan ZHU ; Yongqiang WEI ; Dan XU
Publication Type:Journal Article
Keywords: Hematologic neoplasms; Invasive fungal infections; Caspofungin
From: Journal of Leukemia & Lymphoma 2009;18(12):729-731
CountryChina
Language:Chinese
Abstract: Objective To study the efficacy and safety of caspofungin for the invasive furlgal infection in hematopathic neoplasms patients.Methods The retrospective study of effeacy,influencing factors and adverse reaction in 64 patients with hematopathic neoplasms have been treated with capofungin from January 2007 to February 2009.The SPSS13.0 software Was used for statistic analysis.Results The overall efficacy in 64 patients was 54.7%.The median of effective time for patients with fever and non-fever were 1(1-10) day and 12.5(2-30) days,respectively.There were no significant difference in age,detection of fungus,duration time of neutropenia,hematopoietic stem cell transplant,sraft versus host disease,immunoppressive agents,CT scans,loading dose of caspofungin and salvage therapy between two groups.Drug-related toxicities was low and reversible. Conclusion This study strongly supported caspefungin as an option for empiric and salvage antifungal therapy,and therapeutic effect of caspefungin was not influenced by immune state,neutrophils and CT scans,drug-related toxicities was low.