Diffusion tensor imaging of association fiber tracts in amnestic mild cognitive impairment
- VernacularTitle:扩散张量成像观察遗忘型轻度认知障碍患者联合纤维束
- Author:
Cheng CHANG
;
Wenbin LI
;
Wenhui XIE
;
Xiaoer WEI
;
Jianliang FU
;
Minghua LI
- Publication Type:Journal Article
- Keywords:
Diffusion tensor imaging;
Amnestic mild cognitive impairment;
Alzheimer disease
- From:Chinese Journal of Medical Imaging Technology
2010;26(1):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of association fiber tracts in patients with amnestic mild cognitive impairment (aMCI), and to assess the application value of diffusion tensor imaging (DTI) in differential diagnosis of aMCI and AD. Methods DTI were performed in 20 patients of aMCI (aMCI group), 20 patients of AD (AD group) and 20 normal control subjects (control group). FA and ADC values were calculated in the regions of interest (ROI) in inferior fronto-occipital fasciculus (IFOF), genu and splenium of corpus callosum, superior longitudinal fasciclesⅡ (SLFⅡ) and cingulated bundles. Results There was significant difference of FA values in inferior fronto-occipital fasciculus and cingulate bundles between aMCI group compared with control group (P<0.05), as well as of FA values in cingulate bundles between aMCI group and AD group (P<0.05). Conclusion Abnormal FA values in inferior fronto-occipital fasciculus and cingulate bundles suggest that DTI can be used as a diagnosis index of aMCI. Furthermore, it is helpful in the differential diagnosis of aMCI and AD.
