Tracing rat nerve tracts with 7.0T Manganese-enhanced MRI
- VernacularTitle:7.0T Mn~(2+)增强MRI追踪大鼠神经传导束
- Author:
Song WEN
;
Gejun GAO
;
Tao YANG
;
Feng DAI
;
Zhongbao TAN
- Publication Type:Journal Article
- Keywords:
Manganese;
Magnetic resonance imaging;
Pyramidal tracts
- From:
Chinese Journal of Medical Imaging Technology
2010;26(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of manganese-enhanced MRI (MEMRI) at 7.0T for tracing nerve tracts in rat brain in vivo. Methods With brain stereotactic apparatus, 0.4 μl Mncl_2 with aqueous solution of 1 mol/L was injected into the right somatosensory cortex of 9 SD rats. MR scan was performed for tracing corticospinal tracts and other coherent nerve tracts pre-, and 24, 48, 72 h, 7 days post-injection with 7.0T micro-MRI system, respectively. Results Corticospinal tracts were showed in intact after Mn~(2+) administration from somatosensory cortex, thalamus, cerebral peduncle to pons at the time point of 24, 48, 72 h and 7 days, while the best tdisplaying was achieved at 24-48 h after Mn~(2+) administration. Simultaneously a small quantity of Mn~(2+) reached the opposite somatosensory cortex through the corpus callosum. Conclusion MEMRI for tracing rat nerve tracts can be showed clearly with 7.0T MRI. The location of manganese-enhanced corticospinal tracts in agreement with the rat brain atlas in stereotaxic is in agreement with that Paxinos' published. MEMRI can display the relationship between the two sides of hemisphere, and may play an important role in investigating the brain function and nerve plasticity after nerve injury in vivo.
