Study of cytogenetic characteristics on myelodysplastic syndrome and acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2012.02.012
- VernacularTitle:骨髓增生异常综合征和急性髓系白血病细胞遗传学特征研究
- Author:
Lina WANG
;
Fang YE
;
Guoxia LI
;
Ning JIA
;
Yumei HE
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Leukemia,myeloid,acute;
Leukemia,monocytic,acute;
Cytogenetics
- From:
Journal of Leukemia & Lymphoma
2012;21(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the cytogenetic characteristics of the patients with acute myelomonocytic leukemia (AML-M4), acute monocytic leukemia (AML-M5)and myelodysplastic syndrome (MDS).MethodsChromosomes of bone marrow cells were prepared by short-term culture.Karyotype analysis was performed in 100 AML-M4,46 AML-M5 and 115 MDS by R-banding technique.Results26 ％ (26/100) AML-M4 had clonal cytogenetic abnormalities which mainly include +8,t(8;21) and -7.26 ％ (12/46) AML-M5 had clonal cytogenetic abnormalities which mainly include +11. 39 ％(45/115)had clonal cytogenetic abnormalities which mainly include +8, Hypodiploid and -7. ConclusionCytogenetic detection is very important for the diagnosis of myelodysplastic syndrome and acute myelocytic leukemia.
