A clinical study for acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2010.12.004
- VernacularTitle:异基因造血干细胞移植后急性移植物抗宿主病临床研究
- Author:
Zhengping YU
;
Jiahua DING
;
Baoan CHEN
;
Chong GAO
;
Yunyu SUN
;
Jian CHENG
;
Gang ZHAO
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Transplantation,homologous;
Graft vs host disease;
HLA antigens;
Tissue donors;
Regression analysis
- From:
Journal of Leukemia & Lymphoma
2010;19(12):714-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence and risk factors of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods The clinical data of 72 cases allo-HSCT from Oct 2004 to Dec 2008 were analyzed. Thirteen factors possibly correlated with the development of aGVHD were analyzed. Results aGVHD was developed in 32 cases (44.4 %), in which grades Ⅰ aGVHD was 11.1%, gradesⅡaGVHD was 18.1%, and grades Ⅲ-Ⅳ aGVHD was 15.3 %. The univariate analysis showed that diagnosis, the status of disease, use ATG, conditioning regimen, donor type,ABO blood group disparity between donor and recipient, CD34+ cell number, early engraftment and neutropenic infection, HLA locus were associated with the occurence of aGVHD (P ＜0.1). On the COX regression mode, an increased risk of aGVHD was associated with HLA mismatch (HR =2.58, P ＜0.005), GVHD prophylaxis without ATG (HR =2.94, P ＜ 0.001), and unrelated donor (HR =1.97, P ＜0.01). Conclusion aGVHD is a common complication after allo-HSCT, and HLA mismatch and unrelated donor are independent risk factors for aGVHD.
