Antibiotic Prophylaxis in Endoscopic Retrograde Cholangiopancreatography.
- Author:
Chang Seop KIM
1
;
Kyu Taek LEE
;
Jong Kyun LEE
;
Sang Goon SHIM
;
Mun Suk CHOI
;
In Kyung SUNG
;
Poong Lyul RHEE
;
Jae Jun KIM
;
Kwang Cheol KOH
;
Seung Woon PAIK
;
Jong Chul RHEE
;
Kyoo Wan CHOI
Author Information
1. Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Antibiotic prophylaxis;
Endoscopic retrograde cholangiopancreatography
- MeSH:
Anti-Bacterial Agents;
Antibiotic Prophylaxis*;
Bacteremia;
Cholangiopancreatography, Endoscopic Retrograde*;
Ciprofloxacin;
Citrobacter;
Humans;
Prospective Studies;
Sepsis
- From:Korean Journal of Gastrointestinal Endoscopy
1999;19(6):925-929
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND AIMS: Prophylactic antibiotics are used in an attempt to avoid the septic complications of endoscopic retrograde cholangiopancreatography (ERCP). But, there is individual tendency to choose prophylactic antibiotics due to a lack of definite guidelines for prophylactic antibiotics. Therefore, the effectiveness of ciprofloxacin to prevent post ERCP infectious complications was evaluated. METHODS: One hundred patients underwent 75 diagnostic ERCPs and 25, therapeutic ERCPs. They were classified randomly into a group of 51 prophylaxis (ciprofloxacin 200 mg i.v. 30 min before the procedure) and 49 controls. Pre- and post-ERCP blood cultures were prospectively performed and surveyed for infectious complications. RESULTS: Sepsis was detected in 4 patients in each group (p>0.05). Two cases were related to diagnostic ERCP and the remaining six cases, therapeutic ERCP (p<0.01). Bacteremia was found in 6 cases, but only two cases (Escherichia coli, Citrobacter freundii) were clinically significant. CONCLUSIONS: The frequency of sepsis following ERCP was not significantly reduced by antibiotic prophylaxis (7.8% vs. 8.2%).
