Relationship of serum CA125 and VEGF with infiltration of NHL cells to bone marrow

VernacularTitle:非霍奇金淋巴瘤患者血清CA125和VEGF水平与骨髓浸润的相关性研究
Author: Ke LIAN ; Qiaohua ZHANG ; Shuling HOU ; Minjie WU ; Xiaobo WU
Publication Type:Journal Article
Keywords: Lymophoma,non-Hodgkin; Bone marrow,infiltration; Lymphoma cell leukemia; CA125; VEGF
From: Journal of Leukemia & Lymphoma 2010;19(5):284-286
CountryChina
Language:Chinese
Abstract: Objective To detect serum CA125 and VEGF in patients of non-Hodgkin lymophoma (NHL) involved in bone marrow and analyse prognostic criteria for NHL. Methods The clinical data of 97 patient were chosen as research objects. They were all first-visit patients. Bone marrow infiltrated with lymphoma cell leukemia of 50 patients were identified by bone marrow aspiration or bone marrow biopsy 46 cases of normal bone marrow were used as controls. The serum CA125 and VEGF were detected by ELISA before treatment. Results Among 97 cases of non-Hodgkin disease, there were 50 cases of bone marrow infiltrated lymphoma cells with a incidence rate of 51.5 %. CA125 and VEGF level in the patients whose bone marrow or lymphoma cell leukemia existed NHL cells was much higher than that of NHL with negative bone marrow infutration (P <0.05). Conclusion CA125 and VEGF can be concluded clinical markers which decide bone marrow or lymphoma cell leukem of the NHL patients whether existed NHL cells or not.