Clinical and pathological features of the sporadic Burkitt's lymphoma
10.3760/cma.j.issn.1009-9921.2009.01.006
- VernacularTitle:散发性Burkitt淋巴瘤的病理学特点
- Author:
Yuanjie HUANG
;
Cuiling LIU
;
Liping GONG
;
Xin HUANG
;
Gehong DONG
;
Yunfei SHI
;
Dandan ZHANG
;
Jing ZHANG
;
Chunju ZHOU
;
Yonghong ZHANG
;
Yan ZHANG
;
Zifen GAO
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Immunohistochemistry;
In situ hibridization,fluorescence;
Diagnosis
- From:
Journal of Leukemia & Lymphoma
2009;18(1):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and pathological features of the sporadic Burkitt's lymphoma(BL),as well as its immunohistochemical and molecular characteristics.Methods 20 cases of sporadic BL were retrospectively studied by analyzing their light microscopy features,immunohistochemical expression,EBV infection detected by in stiu hybridization,chromosomal breakage of c-myc and/or lgH genes by interphase fluorescence in stiu hybridization (FISH),and their clinical manifestation.Results All the 20 cases of sporadic BL occurred in children(3-14 y)including 16 males and 4 females.Microscopically,the medium-sized tumor cells were monomorphic and proliferated in a diffuse pattern showingstarry-skywith numerous karyorrhectic debris.Mitotic figures were frequently seen.Immunohistochemically,the tumor cells were positive for CD20 and CD10,over 95%positive for Ki-67 and negative for TdT,CD99,MPO. No EBV infection wag found by in situ hybridization in 18 cases.Interphase FISH analysis detected c-myc gene breakage or amplification and/or IgH/c-myc gene breakage in all detected 15 cases.Conclusion Sporadic BL is a high-grade malignant B cell lymphoma.The tumor cell proliferation index is very high.Molecular and immunohistochemical analysis could reduce the incidence of misdiagnosis and thus phys a vital role on its correct diagnosis and appropriate therapy.
