Clinical significance of MRD detection in ALL-B of children by FCM

VernacularTitle:流式细胞术检测急性淋巴细胞白血病B细胞系患儿骨髓微小残留病的临床意义
Author: Guoping HAO ; Xiaohuan WANG ; Lei ZHU ; Hong CHANG ; Hongyu SHI ; Yanli CHENG
Publication Type:Journal Article
Keywords: Leukemia,biphenotypic,acute; Flow cytometry; Recurrence; Children; Minimal residual disease
From: Journal of Leukemia & Lymphoma 2012;21(7):427-429
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical significance of minimal residual disease (MRD)detecion in ALL-B of children by flow cytometric (FCM).Methods 52 cases of children with ALL-B were performed bone marrow MRD by FCM analisis after induction therapy,3 moths therapy,and 6 moths therapy.After that,MRD detection was performed every 6 months. According to disease risks, three group were categorized,standard risk (SR),imidiete risk (IR) and high risk(HR).Results After 6 months,SR groups MRD positive cases were 4/21(19 ％),IR groups MRD position cases were 8/23 (35 ％),HR groups MRD position cases were 5/8 (63 ％).9 cases relapsed in all 52 patients.There were significant differrence in replased rate between the positive and negtive MRD (P＜0.001). Conclution The dynamic detection of MRD by FCM can be used to evaluate the therapeutic effect and prognosis of children with ALL-B. It is also useful in adjusting treatment strategy and for following up in children with ALL.