Central nervous system myelomatosis

VernacularTitle:中枢神经系统骨髓瘤
Author: Xuewen WANG
Publication Type:Journal Article
Keywords: Multiple myeloma; Central nervous system; Therapy
From: Journal of Leukemia & Lymphoma 2008;17(5):395-398
CountryChina
Language:Chinese
Abstract: Involvement of the central nervous system(CNS)in multiple myeloma(MM)is very uncommon.and it has been observed in approximately 1% of the MM patients.This review summarizes the clinical and laboratory characteristics and treatment modalities of 109 patients with CNS myelomatosis(CNS MM)reported in the literatures.CNS MM has a wide spectrum of neurological symptoms and signs.No guidelines for therapy of CNS MM are available,which has resulted in a large variation in the treatment schedules.Treatment options include intrathecal chemotherapy(IT),systemic chemotherapy(SC),cranial irradiation(CI)or a combination.The prognosis of CNS MM remains poor,with an overall median survival from the time of diagnosis to death of 2.0 months(range 0.1-25 months).Patients who were treated with CI had a significantly(P=0.004)longer survival time when compared with patients without CI.