A case report of Castleman's disease transformed into Hodgkin's lymphoma with literature review
10.3760/cma.j.issn.1009-9921.2009.11.015
- VernacularTitle:Castleman病转化为霍奇金淋巴瘤一例并文献复习
- Author:
Jing WANG
;
Wenming CHEN
- Publication Type:Journal Article
- Keywords:
Giant lymph node hyperplasia;
Hodgkin diseaseDOI: 10.3760/cma.j.issn. 1009-9921.2009.11.015
- From:
Journal of Leukemia & Lymphoma
2009;18(11):684-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the cause and pathogenesis,clinical and pathological features,diagnosis,treatment and prognosis of Casdeman's disease (CD). Methods One patient with CD which has transformed into Hodgkin's lymphoma in the end was analysed and the review were included. Results Castleman' s disease was a lymphoproliferative disorder with benign hyperplastic lymphnodes histologically characterized by follicular hyperplasia and capillary proliferation with endothelial hyperplasia. Based on the characteristic of pathology it was subdivided into three subtypes, hyaline vascular variant, plasma cell variant and mixed variant. The clinical manifestation of CD was multiplicity,including the lymphadenectasis and the involvement of the muhisystem of the body. The early diagnosis was depended on the histopathology,and the different histopathology has the distinct prognosis. The prognosis of local Castleman's disease (LCD) was good but the muhicentric Casdeman's disease (MCD) was poor. Conclusion The different histopathology of CD were determined according to the different clinical manifestations and prognosis.
