Problems in the treatment of acute promyelocytic leukemia

VernacularTitle:治疗急性早幼粒细胞白血病的几个问题
Author: Fengru LIN ; Xiaonan GUO ; Jinhai REN
Publication Type:Journal Article
Keywords: Leukemia,myeloid; Therapy
From: Journal of Leukemia & Lymphoma 2011;20(1):11-14
CountryChina
Language:Chinese
Abstract: Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia, is characterized by rapid progress, prone to developing DIC, and high mortality. Typical chromosome translocation with PMLRARα fusion gene occurs in more than 95% of APL cases. Since 1986, the outcome of APL has been significantly improved in our country by firstly using ATRA and ATO for treating APL, making APL of AML curable by chemotherapy only. Based on our limited experiences, we discussed the related problems in the treatment of APL.