The central nervous system complications after hapilo-matched non-ablative peripheral blood hematopoietic stem cells transplantation for malignant hematological disease
10.3760/cma.j.issn.1009-9921.2010.12.005
- VernacularTitle:单倍体相合非清髓造血干细胞移植治疗恶性血液病术后中枢神经系统并发症
- Author:
Qingchao WU
;
Zhaohui WANG
;
Bo HAN
;
Chuanbo FAN
;
Qing HONG
;
Jiuhe WANG
;
Junling LIU
- Publication Type:Journal Article
- Keywords:
Haploidy;
Stem cell transplantation;
Central nervous system;
Postoperative complications;
Risk factors
- From:
Journal of Leukemia & Lymphoma
2010;19(12):718-720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence ,clinical and neuroimaging features, possible risk factors and outcome of central nervous system (CNS) complications one year after hapilo-matched non-ablative hematopoietic stem cells transplantation. Methods The medical records of 36 consecutive patients who underwent hapilo-matched non-ablative hematopoietic stem cells transplantation for malignant and nonmalignant hematologic diseases between February 2004 and May 2009 were reviewed. Results CNS complications occurred in six (16.7 %) patients. Four of the six patients (66.7 %) died. Cerebral infarction occurred in three (8.3 %) patients. Cerebral softenness occurred in two (5.6 %) patients. Cerebral hemarrage occurred in 1 (2.8 %) patient. Epilepsy occurred in 1 (2.8 %) patient. The CNS complications occurred between 12 days and 286 days after stem cells transplantation. The age illness status and death rate were statistically different compared to patients without CNS complications (P ＜0.05). Conclusion The incidence and mortality of CNS complications are higher in those who underwent hapilo-matched non-ablative hematopoietic stem cells transplantation,which will make impacts on the patients' life quality and outcome.The illness status and eldly are probably the risk factors.
