Contrast-enhanced ultrasound in assessing renal cortical and medullary perfusion in acute renal failure in rabbits
- VernacularTitle:超声造影观察兔急性肾衰竭前后肾皮、髓质血流灌注变化
- Author:
Zhi JIANG
;
Xiaoling HUANG
;
Hong YANG
;
Yong ZHANG
;
Wenfang ZHANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
contrast media;
Rabbits;
Kidney failure;
acute;
Blood perfusion
- From:
Chinese Journal of Interventional Imaging and Therapy
2010;7(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the application of contrast-enhanced ultrasound (CEUS) in evaluation of the renal cortical and medullary perfusion changes before and after acute renal failure (ARF) in rabbits. Methods Rabbit ARF models were established with intramuscular 50% glycerin (12-15 ml/kg) injection into rabbits' thighs. One day before and after ARF models establishment, CEUS was performed on each rabbit. The renal perfusion time-intensity curve (TIC) was analyzed, including parameters like AT (arrival time), TTP (time to peak intensity), A (amplitude of peak intensity), AUC (area under the curve), β (slope rate of TIC) of renal cortex and medulla. Results The value of A and β before model establishment was (17.36±13.73) dB and (5.38±2.08) dB/s, respectively, both was significantly higher than those after glycerin injection ([6.59±4.25] dB and [1.58±1.41] dB/s, respectively) (P<0.05). The value of TTP and AUC before model establishment was (2.46±1.76) s and (329.31±171.70) dBs, both was significantly lower than those after injection ([5.93±4.80] s and [722.28±354.14] dBs, respectively) (P<0.05). No significant difference was found in AT of renal cortex and AT, A, TTP, AUC, β of renal medulla, nor in SCr or BUN. Conclusion CEUS can display the changes of perfusion image of the renal cortex of the ARF earlier than SCr and BUN.
