Caspase recruitment domain 11 and diffuse large B-cell lymphoma

VernacularTitle:胱冬肽酶募集结构域与弥漫性大B细胞淋巴瘤
Author: Fangfang LIU ; Junhui GE
Publication Type:Journal Article
Keywords: Lymphoma,large-cell,diffuse; NF-kappa B; Therapy; CARD11
From: Journal of Leukemia & Lymphoma 2010;19(11):702-704
CountryChina
Language:Chinese
Abstract: Diffuse large B-cell lymphoma (DLBCL) represents the most common type of malignant lymphoma. DLBCL is heterogeneous with respect to morphology, immunophenotype, biology, clinical presentation and outcome. Constitutive activity of the NF-κB pathway may contribute to the poor prognosis of patients with activated B cell-like (ABC) subgroup of DLBCL, caspase recruitment domain 11 (CARD11) is the important signal protein in the signaling pathway of NF-κB. Furthermore, various pre-clinical data have proved the importance of CARD11 in DLBCL. This review summarizes the biological characteristics of CARD11, and its relationship with NF-κB signaling transduction pathway and the outcome of DLBCL, so that we can better understanding the pathogenesis and new therapeutic target of DLBCL.