Intratumoral relative perfusion rate and the relation between MVD and expression of VEGF assessed with power Doppler imaging: in bladder carcinoma
10.3321/j.issn:1003-3289.2009.07.031
- VernacularTitle:能量多普勒检测膀胱癌血流相对灌注率及其与MVD、VEGF表达的相关性
- Author:
Hongying LUO
;
Hui LI
;
Yanxia XIE
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Ultrasonography,Doppler;
Vascular endothelial growth factor;
Microvessel density
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1232-1234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between relative perfusion rate assessed with power Doppler imaging (PDI) and microvessel density (MVD), as well as expression of vascular endothelial growth factor (VEGF) in bladder carcinoma. Methods The transrectal ultrasound (TRUS) blood flow signal of bladder carcinoma was preoperatively detected with color Doppler imaging in 45 patients, and the relative perfusion rates were obtained for analysis. MVD and the expression of VEGF of excised tumor were assessed immunohistochemically. Results There were correlation between relative perfusion rate and MVD, the expression of VEGF. MVD and the expression of VEGF were related to pathologic grade and the invasiveness of tumor tissues. The expression of VEGF in bladder carcinoma was positively correlated to the tumor interstitial vascular density. Conclusion Combination of PDI and immunohistochemical parameters is useful for evaluating the angiogensis of bladder carcinoma from a different point of view.
