Effect of cyclosporine-A on electrophysiological properties of atria in tachycardia-induced atrial fibrillation
- Author:
Lei GAO
;
Wei YAN
;
Yuqi LIU
;
Ya HUANG
;
Qi CHEN
;
Yuxiao ZHANG
;
Peng LIU
;
Caiyi LU
- Publication Type:Journal Article
- Keywords:
attral fibrillation;
calcineurin;
CsA:electrophysiology;
electrical remodeling
- From:
Journal of Geriatric Cardiology
2008;5(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ciyelosporine-A(CsA).a calcinenrin(CAN)inhibitor,on electrophysiological propertiesof atria in canine tachycardia-induced model of AF.Methods Eighteen healthy adult mongrel canines weighing 17.0 to 23.2 kg(rangedfrom 2 to 4 years old)were randomized to 3 groups,Sham group(no pacemaker was implanted),atrial tachypacing group(ATP group)each group at baseline and after 8 weeks' tachypacing.Measurements included atrial effective refractory period(AERP),conductionvelocity(CV),wave length(WE),atrial fibrillation load and rate-adaptability. Results After 8 weeks' atrial tachypacing,ATP andCsA groups showed significant longer duration of the P wave,shorter AERP,decreased adaptation of AERE slower CV,shorter Wland longer AF duration compared to the shamg roup (all P＜0.05).AERP of the CsA group was longer than that of ATP group (P＜0.05),but there were no differences in rate-adaptability,CV,incidence of induced AF and AF duration between CsA group and ATP group.Conclusions Our results suggest that calcineurin pathway intervention by CsA have a positive effect on tachycardia-inducedelectrical remodeling of atria,but can not prevent or reverse AF.
