Relationship between platelet P-selectin and severity of acute coronary syndromes
- Author:
Rui WANG
;
Jiyuan LU
;
Yongping JIA
;
Yuping GAO
;
Chunyu FAN
;
Fang LI
- Publication Type:Journal Article
- Keywords:
platelets;
P-selectin;
acute coronary syndromes
- From:
Journal of Geriatric Cardiology
2008;5(3):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective Recent studies reveal important roles of platelet P-seleetin on progression of atherosclerosis.In the present study,we examine the relation between Platelet P-selectin expression and severity of acute coronary syndromes.Methods One hundredand eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes(ACS)were enrolled in the study.Level of P-selectin expression was determined bv flow cytometry.Platelet P-selectin level was expressed as the percentage of P-selectin positive platelet.Results The level of P-selectin was higher in patients with a single diseased coronary artery or multiplediseased arteries compared to thOSe with normal coronary arteries.P-selectin expression was significantly and positively correlatedwith angiographic Gensini score(r=0.323,P=0.029).Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with ACS was independent of other clinical factors. Conclusions Platelet P-selectin is associated withseverity of acute coronary syndromes in patients with acute coronary syndromes.
