Calcineurin signalling mechanisms in myocardial hypertrophy
- Author:
Jianchun WANG
;
Yong ZHAO
;
Jianhua SHAO
- Publication Type:Journal Article
- Keywords:
Calcineurin;
signal transduction;
hypertrophy
- From:
Journal of Geriatric Cardiology
2010;07(3):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we used literatures on MEDLINE (2000-2011), systematically reviewed the new development of calcineurin signaling pathway in myocardial hypertrophy.
