Diffusion-weighted imaging in predicting and monitoring the response of uterine cervix cancer to concurrent chemoradiation
10.3321/j.issn:1003-3289.2009.07.042
- VernacularTitle:扩散加权成像预测、监测宫颈癌放化疗效果
- Author:
Ying LIU
;
Renju BAI
;
Haoran SUN
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Diffusion-weighted imaging;
ADC value;
Chemoradiotherapy
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1269-1272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of diffusion-weighted imaging (DWI) in predicting and monitoring the response of uterine cervix cancer to concurrent chemoradiation. Methods Seventeen patients with uterine cervix cancer underwent conventional MRI and DWI examinations before therapy and at one month and two months after the initiation of concurrent chemoradiation, and 8 of them underwent additional examinations at 15 d after therapy. The longest diameter of tumor before and after treatment was measured on axial T2WI. The mean ADC value among pre- and post-treatment of each group (CR, PR and SD) was compared. Results The mean ADC value before therapy of CR group was statistically lower than that of PR group (P＜0.05). There was negative correlation between mean pretreatment ADC value and percentage size reduction of tumor after concurrent chemoradiation at two months (r=-0.574, P＜0.05). The percentage ADC change of tumor at one month correlated positively with percentage size reduction of tumor at two months after concurrent chemoradiation (r=0.572, P＜0.05). Fifteen days after the initiation of concurrent chemoradiation, the mean ADC value of 8 patients increased significantly, however, the longest diameter of tumor showed no statistically significant changes compared with pre-treatment tumor diameter. Conclusion DWI has the ability to predict the response of uterine cervix cancer to concurrent chemoradiation, and it can monitor the treatment response as well.
