Prediction of acute response to cardiac resynchronization therapy with two-dimensional speckle tracking echocardiography in congestive heart failure patients
- VernacularTitle:二维超声斑点追踪预测充血性心力衰竭患者心脏再同步化治疗的急性期反应
- Author:
Chunyan MA
;
Shuang LIU
;
Weidong REN
;
Bo YU
;
Li TANG
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Cardiac resynchronization therapy;
Heart failure
- From:Chinese Journal of Medical Imaging Technology
2010;26(2):278-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of two-dimensional speckle tracking echocardiography (2D-STE) of predicting the acute response to cardiac resynchronization therapy (CRT) in patients with congestive heart failure. Methods Twenty-four patients with congestive heart failure scheduled for CRT were included. 2D-STE was performed within 7 days of implantation with device ON and OFF. Left ventricular (LV) dyssynchrony was defined as an interval ≥130 ms for the absolute difference in time to peak radial strain for the anteroseptal wall versus the posterior wall (T_(AS-POST)) with 2D-STE. Acute hemodynamic response was measured as LVdp/dt, and percentage change in LVdp/dt was used to classify responders (Δdp/dt%＞25%) and nonresponders (Δdp/dt%≤25%). Results Fifteen patients (62.50%) were classified as acute responders. Compared with nonresponders, the responders demonstrated significant increase of LV ejection fraction and reduction of TAS-POST after CRT-ON. T_(AS-POST)was the only determinants of Δdp/dt%＞25%. T_(AS-POST)≥130 ms prognosticated acute response to CRT with sensitivity of 86.24% and specificity of 70.38%. Conclusion CRT can immediately increase the LV systolic function and synchrony. 2D-STE is highly predictive for acute response to CRT.
