Research progress of aspartyl-(asparaginyl) β-hydroxylase in tumors
10.3760/cma.j.issn.1006-9801.2015.04.020
- VernacularTitle:天冬氨酸(天冬酰胺酰)β羟化酶在肿瘤中的研究进展
- Author:
Fang LYU
- Publication Type:Journal Article
- Keywords:
Aspartyl-(asparaginyl) β-hydroxylase;
Neoplasms;
Diagnosis
- From:
Cancer Research and Clinic
2015;27(4):280-282
- CountryChina
- Language:Chinese
-
Abstract:
Aspartyl-(asparaginyl) β-hydroxylase (AAH) is a type 2 transmembrane protein and a member of the α-ketoglutarate-dependent dioxygenase family of proteins.AAH catalyzes hydroxylation of specific aspartyl and asparaginyl residues in epidermal growth factor-like domains of proteins.Overexpression of AAH is found in many types of cancer tissues,however,AAH expression is found only in normal placenta and paranephros tissues.AAH can translocate to cell membrane from endoplasmic reticulum membrane when it is overexpressed in cancer cell,which hydroxylate proteins such as Notch,Jagged,and cellular adhesion molecules that regulate cell migration and invasion.AAH is a potential biomarker for cancer diagnosis.
