Advances in research of microRNA and B-cell lymphoma
10.3760/cma.j.issn.1006-9801.2015.04.019
- VernacularTitle:微小RNA在B细胞淋巴瘤中的研究进展
- Author:
Yanyan ZHANG
- Publication Type:Journal Article
- Keywords:
microRNA;
Biosynthesis;
Post-transcriptional regulation;
Lymphoma,B-cell
- From:
Cancer Research and Clinic
2015;27(4):277-280
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a class of small single-stranded and non-coding RNAs that negatively regulate gene expression at the post-transcriptional level by degradation of target mRNA or inhibition of protein translation.Recent studies have shown that miRNAs play important roles in human diseases.It is of great importance to explore the role of miRNAs in the pathogenesis,early diagnosis and new therapeutic strategies of a variety of malignant tumors,including B-cell lymphoma.This review described the biosynthesis of miRNAs,the mechanisms of miRNAs target regulation and the involvement of miRNAs in the initiation and progression of human cancers,and summarized the role of miRNAs in B-cell lymphoma.
