The expression and significance of E-cadherin and β-catenin in type Ⅰ endometrial carcinoma
10.3760/cma.j.issn.1006-9801.2015.03.009
- VernacularTitle:E-钙黏蛋白和β-连环蛋白在Ⅰ型子宫内膜癌中的表达及其意义
- Author:
Lingling YUAN
;
Xiaohong GONG
;
Ping LIU
;
Tieyan WANG
;
Xianbin TANG
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
E-cadherin;
β-catenin;
Immunohistochemistry
- From:
Cancer Research and Clinic
2015;27(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of E-cadherin and β-catenin in type Ⅰ endometrial carcinoma.Methods The expression of E-cadherin and β-catenin were detected by immunohistochemistry in 60 patients with type Ⅰ endometrial carcinoma and 10 normal endometrial tissues.The patients were followed-up postoperatively for the survival rate.Results Expression of E-cadherin and β-catenin in 10 normal endometrial tissues was all high expression,while those of both abnormal expression in type Ⅰ endometrial carcinoma with expression rates with 60.0 ％ (36/60) and 55.0 ％ (33/60),respectively,which were difference compared with both in normal endometrial tissues (P ＜ 0.05).The expression rates were markedly decreased in carcinoma with lymph node metastasis than those without lymph node metastasis.The proportions of abnormal expressions of E-cadherin and β-catenin were positively correlated with tumor grade and myometrial invasion in type Ⅰ endometrial carcinoma (P ＜ 0.05).The postoperative two-year survival rate in the patients with abnormal expression of E-cadherin and β-catenin were much lower than those with normal expression (P ＜ 0.05).Conclusions Abnormal high expression of E-cadherin and β-catenin may play important roles on generation and metastasis in type Ⅰ endometrial carcinoma.Both of them may be promising method for predicting invasion and metastasis and can be prognostic predictors in type Ⅰ endometrial carcinoma.
