Clinical Significance of CK19, CD56 and p53 in differential diagnosis of papillary thyroid microcarcinoma and thyroid papillary hyperplasia
10.3760/cma.j.issn.1006-9801.2015.03.008
- VernacularTitle:CK19、CD56和p53在甲状腺微小乳头状癌和甲状腺乳头状增生鉴别诊断中的意义
- Author:
Jie NAN
;
Hongkun WANG
;
Hong XIAO
;
Huixia ZHENG
- Publication Type:Journal Article
- Keywords:
Papillary thyroid microcarcinoma;
Thyroid papillary hyperplasia;
CK19;
CD56;
p53
- From:
Cancer Research and Clinic
2015;27(3):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and diagnostic significance of CK19,CD56 and p53 protein in papillary thyroid microcarcinoma and thyroid papillary hyperplasia.Methods The expressions of CK19、CD56 and p53 protein were detected in 52 cases of papillary thyroid microcarcinoma and 31 of thyroid papillary hyperplasia by iImmunohistochemical methods.Results The positive rate of CK19 expression was 100 ％ (52/52) of papillary thyroid microcarcinoma and 29.0 ％ (9/31) in 31 of thyroid papillary hyperplasia.There was significant difference between two groups (P ＜ 0.001).CK56 in 2 cases (3.8 ％) of papillary thyroid microcarcinoma appeared mild positive expression,and in 20 cases (66.7 ％) of thyroid papillary hyperplasia positive expression (P ＜ 0.001).The positive expression rates of p53 were 69.2 ％(36/52) in papillary thyroid microcarcinoma and 6.5 ％ (2/31) in thyroid papillary hyperplasia (P ＜ 0.001).Conclusion CK19,CD56 and p53 may be important value on differential diagnosis of papillary thyroid microcarcinoma from thyroid papillary hyperplasia,and they are the indispensable markers of differential diagnosis.
