Relationship between thrombocytosis and effect of chemotherapy, prognosis in patients with advanced non-small cell lung cancer

VernacularTitle:晚期非小细胞肺癌患者血小板计数与化疗效果及预后的关系
Author: Liyan GU ; Xin WANG ; Yan WANG ; Lili ZENG ; Diansheng ZHONG
Publication Type:Journal Article
Keywords: Carcinoma,non-small-cell lung; Platelet count; Thrombocytosis; Prognosis
From: Cancer Research and Clinic 2015;27(1):35-38
CountryChina
Language:Chinese
Abstract: Objective To study the prevalence of thrombocytosis in patients with non-small-cell lung cancer (NSCLC) and its correlation with clinicopathological features.Methods 156 patients with advanced NSCLC were retrospectively analyzed.The platelets degree between the groups with different sex,age,smoking,histological type of advanced NSCLC was compared and analyzed statistically.The relationship between the platelet count and chemotherapy effects was analyzed.Single analysis and Cox regression analysis were used for TTP and OS.Results Compared with the healthy persons,Plt significantly elevated in group with advanced NSCLC (36.5 ％,57/156 vs 5.0 ％,5/100) (P ＜ 0.01),and thrombocytosis group responded poorly to chemotherapy (22.8 ％,13/57 vs 39.4 ％,39/99) (P ＜ 0.05).The TTP (3.0 months vs 5.2 months) and OS (11.2 months vs 14.2 months) of Plt elevated group were significantly shorter than those of normal group.Conclusion Thrombocytosis is closely related to progress and metastasis of advanced NSCLC.Platelet count can be used as an assistant index in the prognosis judgment of patients with advanced NSCLC.