The expression level of miR-125a-5p in colorectal cancer with various differentiation

VernacularTitle:miR-125a-5p在不同分化程度结直肠癌中表达水平的研究
Author: Xiaobing WU ; Xuehu XU ; Shangbiao WU ; Qingping JIANG ; Haibo LIU ; Rong CHEN ; Yan SUN
Publication Type:Journal Article
Keywords: Colorectal neoplasms; miR-125a-5p; Differentiation stage; Diagnosis
From: Cancer Research and Clinic 2014;26(12):801-804
CountryChina
Language:Chinese
Abstract: Objective To identify the expression level of miR-125a-5p in colorectal cancer (CRC) with various differentiation,and to investigate its diagnostic significance.Methods Real-time polymerase chain reaction was used to analyze the expression level of miR-125a-5p in tumors and paired normal tissues of different differentiated CRC.Receiver-operating-characteristic (ROC) curve was performed to evaluate the specificity and sensitivity of using miR-125a-5p as biomarkers to discriminate CRC patients from normal persons.Results Compared with normal tissues,miR-125a-5p was down-regulated in both high and moderate differentiation,miR-125a-5p could distinguish CRC from normal persons with high sensitivity and specificity,which were 80.00 ％ and 90.00 ％,respectively.Conclusions miR-125a-5p down-regulated in CRC indicates that miR-125a-5p contributes to tumorigenesis,and may be a potential biomarker for CRC.