Observation of the clinical effect of individualized chemotherapy which was designed according to genetic characters in patients with advanced cancer

VernacularTitle:基于基因检测的个体化化疗方案治疗晚期肿瘤
Author: Yufei FAN ; Dong REN ; Yuan QIN ; Dinggang LI ; Xiaolin LIU ; Yonghua HU ; Cuihong WANG
Publication Type:Journal Article
Keywords: Advanced cancer; Individualized chemotherapy; Effect
From: Cancer Research and Clinic 2014;26(11):763-766
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of individualized chemotherapy plans which was designed depend on secific genetic characters in patients with advanced cancer.Methods The surgery or biopsy specimen samples from 25 patients with advanced recurrent tumors (study group) were analyzed.Different gene mRNA expressions were detected by PCR and sequencing.According to detection results,the most appropriate chemotherapy would be applied on 25 cases patients of study group.The chemotherapy from traditional experience and evidence-based medical evidence were applied for 20 cases patients of control group.The difference of RR and disease control rate (DCR) between two groups were compared.Results The DCR and RR were 84 ％ (21/25) and 44 ％ (11/25) in study group,35 ％ (7/20) and 15 ％ (3/20) in control group.The DCR and RR in study group were significantly higher than those in control group (P ＜ 0.01).Conclusion Individualized chemotherapy could improve the efficient and prolong the survival period of the patients with advanced recurrent tumors.