Expression and significances of Merlin and mTOR in spinal schwannoma
10.3760/cma.j.issn.1006-9801.2015.04.009
- VernacularTitle:椎管内神经鞘瘤mTOR及Merlin蛋白的表达及其意义
- Author:
Shengze LIU
;
Kaichuang ZHANG
;
Yongliang ZHANG
;
Jian LIN
;
Shi CHEN
- Publication Type:Journal Article
- Keywords:
mTOR;
Merlin protein;
Schwannoma;
Immunohistochemistry
- From:
Cancer Research and Clinic
2015;27(4):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the expression and clinicopathological significances of mTOR and Merlin proteins in spinal schwannoma.Methods Immunohistochemical SP method was used to detect the expression levels of mTOR and Merlin proteins in tumor tissues from 21 spinal schwannoma patients.The meaning of the two proteins expression changes on schwannoma was analyzed.Results In 21 cases of schwannoma patients,the mTOR was positive expression in 16 cases,negative expression in 5 cases,while in the normal neural tissue,mTOR was all negative expression.In 21 cases of schwannoma patients,the Merlin protein was negative expression in 18 cases,positive expression in 3 cases,but it was positive in all of normal neural tissue.Merlin protein expression was negatively correlated with mTOR protein expression (r =-0.785,P ＜ 0.001).Conclusion The expression level of mTOR proteins in schwannoma is significantly higher than that in normal nerve tissue,while the expression level of Merlin protein in schwannoma tissue is significantly lower than that in normal nerve tissue.There is an internal relationship between mTOR and Merlin.
