Significance of CD34 expression in thymic tumor
10.3760/cma.j.issn.1006-9801.2015.03.012
- VernacularTitle:CD34在胸腺肿瘤亚型中的表达及其意义
- Author:
Lujun WEI
;
Linhao XU
- Publication Type:Journal Article
- Keywords:
Thymic tumor;
CD34;
Immunohistochemistry
- From:
Cancer Research and Clinic
2015;27(3):187-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD34 and its clinical significances in different types of thymic tumor.Methods The expressions of CD34 in 61 thymic tumor tissues were detected by SP immunohistochemical method,then,the MVD was calculated.The patients included 7 cases of type A,9 cases of type AB,16 cases of type B1,10 cases of type B2,10 cases of type B3 and 9 cases of type C according to 2004 WHO Classification of thymic tumor.Results CD34 expression level was significantly increased from type A to type C.The MVDs were 3.78±2.12,5.72±2.79,7.51±3.34,10.89±5.10,12.31±4.08 and 16.51±6.24 in A,AB,B1,B2,B3 and C type of thymic tumor (F =2.048,P =0.047).The expression level in B2+B3+C type was significantly higher than A+AB+B1 type (t =6.034,P ＜ 0.05).Conclusions The expression of CD34 in different types of thymic tumor suggests that it may take some action in tumor-associated angiogenic function.Detection of CD34 may be useful to evaluate malignancy of thymic tumor.
