Study of level Ⅰb delineation, dose analysis and regional recurrence in level Ⅰb lymph node-negative nasopharyngeal carcinoma patients treated by intensity-modulated radiotherapy
10.3760/cma.j.issn.1006-9801.2015.01.007
- VernacularTitle:调强适形放疗治疗颈部Ⅰb区淋巴结阴性鼻咽癌Ⅰb区勾画、剂量及区域复发的研究
- Author:
Mei LI
;
Xiaoguang HUANG
;
Zhining YANG
;
Yizhou ZHAN
;
Zhixiong LIN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Intensity-modulated radiotherapy;
Prophylactic irradiation
- From:
Cancer Research and Clinic
2015;27(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level Ⅰb contouring,dose analysis and regional recurrence in level Ⅰb lymph node-negative (Ⅰb-negative) nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiotherapy (IMRT).Methods One hundred ninety newly-diagnosed,Ⅰb-negative NPC patients treated by IMRT were enrolled.Level Ⅰb contouring and dose prescribing in this cohort were classified into planned prophylactic irradiation (PPI) group (56 cases) and non-planned prophylactic irradiation (non-PPI) group (134 cases).The mean dose (Dmean) of the level Ⅰb bilaterally and submandibular glands (SMGs) was recorded for comparison.Results After a median follow-up of 47 months,there was no level Ⅰb regional recurrences noted in the entire group.The mean doses of level Ⅰb and the submandibular glands were significantly lower in the non-PPI group than those in the PPI group as follows:(50.81±5.37) Gy vs (59.68±3.32) Gy for the left level Ⅰb,(51.55±5.02) Gy vs (59.66±3.85) Gy for the left submandibular gland,(51.55±5.02) Gy vs (59.66±3.85) Gy for the right level Ⅰb and (57.25±4.69) Gy vs (63.41±2.88) Gy for the right submandibular gland (all P =0.000).Conclusion In this retrospective analysis of non-randomized single institute data,it seems unlikely that PPI to level Ⅰb is necessary in Ⅰb-negative NPC patients treated by IMRT.
