Research progress of anticancer effect of tanshinone ⅡA in vivo
10.3760/cma.j.issn.1006-9801.2014.12.019
- VernacularTitle:丹参酮ⅡA体内抗肿瘤作用的研究进展
- Author:
Xinliang LU
- Publication Type:Journal Article
- Keywords:
Tanshinone ⅡA;
Neoplasms
- From:
Cancer Research and Clinic
2014;26(12):854-856
- CountryChina
- Language:Chinese
-
Abstract:
Tanshinone Ⅱ A is effective to treat a great variety of diseases,and recently its potential anticancer activity has attracted great attention.While studies in vitro indicate that tanshinone Ⅱ A is toxic in a number of cell types and affects differentiation and apoptosis,but anticancer effects in vivo remain to be elucidated.Tanshinone Ⅱ A varies widely in production quality,method of administration (oral,intravenous,subcutaneous,and so on),usage and dosage.Tanshinone Ⅱ A s limited hydrophilicity,poor intestinal absorption,low oral efficacy,and other pharmacologic characteristics have impacted both its usage and elucidation of efficacy and mechanisms in vivo,which are the focus of future research.
