Expression and regulation of miR-34b and the research progress of its function in tumorigenesis

VernacularTitle:miR-34b表达调控及其在肿瘤发生中作用的研究进展
Author: Xiujun SONG ; Fengsheng LI
Publication Type:Journal Article
Keywords: MicroRNA; miR-34b; p53; Methylation; Neoplasms
From: Cancer Research and Clinic 2014;26(12):851-853
CountryChina
Language:Chinese
Abstract: miRNA is a kind of small,endogenous noncoding RNA which regulates gene expression in post-transcription level and is highly conserved and tissue-specificity,miRNA generally participates the regulation of many complicated vital process,such as cell growth,development and also plays an important role in the pathogenesis of many kinds of tumors,miR-34b is a newly discovered miRNA,which is regulated by p53,promoter methylation and so on.miR-34b can regulate cellular proliferation and apoptosis,and also involves in the generation and regulation of tumor,which suggests wide application prospect in therapy and prognosis of tumor.This review will focus on the progress of miR-34b and its relationship with tumor.