Expression of heat shock protein 5 in breast carcinoma and its significance

VernacularTitle:热休克蛋白5在乳腺癌组织中的表达及其意义
Author: Bing LI ; Jinping XU ; Xuejun ZHAO ; Zhongying WANG ; Haiyun ZHU
Publication Type:Journal Article
Keywords: Heat shock protein; Breast neoplasms; Immunohistochemisty
From: Cancer Research and Clinic 2014;26(12):834-836
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of heat shock protein 5 (HSPA5) in breast carcinoma and to study its relationship with clinical and pathological factors.Methods HSPA5 from 97 cases of breast carcinoma and 40 cases of adjacent tissues of breast carcinoma were examined by immunohistochemical method.Results The overall positive rate of HSPA5 in 97 cases of breast cancer was 81.4 ％ (79/97).The positive rates of HSPA5 in cancer tissues and paired normal tissues were 32.5 ％ (13/40) and 7.5 ％ (3/40),respectively.The expression rate of HSPA5 in tumor tissues was significantly higher than that in normal tissues (x2 =7.813,P =0.038).The expression of HSPA5 in breast carcinoma was correlated with histologic grade and lymph node metastasis (x2 =22.233,P =0.007; x2 =5.342,P =0.024).Conclusion The occurrence of breast carcinoma and the formation of invasion may be related with overexperssion of HSPA5.