Clinical efficacy of CT-guided 125I particles implantation combined with GS regimen in treatment of locally advanced pancreatic cancer
10.3760/cma.j.issn.1006-9801.2014.12.009
- VernacularTitle:CT引导下125I粒子植入联合吉西他滨及替吉奥治疗局部晚期胰腺癌
- Author:
Junling ZHAO
;
Junjie LUN
;
Jianye SUN
;
Xiaokun HU
;
Haozhi YIN
- Publication Type:Journal Article
- Keywords:
Spancreatic neoplasms;
125I particles;
Gemcitabine;
S-1
- From:
Cancer Research and Clinic
2014;26(12):823-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of CT-guided 125I particles implantation combined with gemcitabine plus S-1 (GS) regimen in the treatment of locally advanced pancreatic cancer.Methods 42 patients with unresectable local advanced pancreatic cancer were given with CT-guided 125I seed implantation.3-4 cycles of GS regimen was given based on the tolerance of patient s body within 3-7 d after implantation of particles.Review of blood,CA199,chest X-ray,CT scan + enhanced or MRI were performed at 2nd,4th,6th,12th month after surgery.Results 2nd,4th,6th month after surgery,tumor lesions were significantly reduced,ORRs were 59.5 ％ (25/42),66.7 ％ (28/42) and 73.8 ％ (31/42),respectively,DCRs were 83.3 ％ (35/42),78.6 ％ (33/42) and 76.2 ％ (32/42),respectively.No serious adverse reactions were observed,patient could tolerate these reactions.The 6th,12th,24th month survival rates were 100 ％ (42/42),47.6 ％ (20/42) and 11.9 ％ (5/42),respectively,mPFS was 8.27 months and mOS was 12.00 months.Conclusion CT-guided 125I particles implantation combined with GS regimen is convenient,safe,high efficacy in the treatment of locally advanced pancreatic cancer.
