Research progress of driver mutations in non-small cell lung adenocarcinoma
10.3760/cma.j.issn.1006-9801.2014.10.017
- VernacularTitle:非小细胞肺腺癌驱动突变的研究进展
- Author:
Yi MENG
- Publication Type:Journal Article
- Keywords:
Neoplasms,non-small cell lung;
Adenocarcinoma;
Driver mutations;
Individualized treatment
- From:
Cancer Research and Clinic
2014;26(10):703-707
- CountryChina
- Language:Chinese
-
Abstract:
With the development of the main tumor gene sequencing projects,driver mutations have been put into the highlight due to its significant meaning on the cancer occurrence,development as well as treatment.In the past decade,based on the finding of new driver mutations,the knowledge of non-small cell lung cancer (NSCLC) have been improved from the traditional pathological classification to the current molecular classification.Meanwhile,NSCLC patients are no longer looked as an assembly of the same type tumor but various individuals with different molecular biology behavior with the different sensitivity to the targeted drugs.This article focuses on the recent discovery advances of driver mutations in lung adenocarcinoma.
