Research progress of octamer-binding transcription factor 4 and sal-like gene 4 in germ cell tumors

VernacularTitle:八聚体结合转录因子4、婆罗双树样基因4在生殖细胞肿瘤中的研究进展
Author: Yaqin CUI
Publication Type:Journal Article
Keywords: Germ cell tumors; Octamer-binding transcription factor 4; Sal-like gene 4
From: Cancer Research and Clinic 2014;26(9):646-648
CountryChina
Language:Chinese
Abstract: Tumor marker research is a hot field of oncology.Previous studies of tumor markers such as placental alkaline phosphatase,alpha-fetoprotein,c-kit and CD30 and so on,lack sufficient sensitivity and specificity for the early diagnosis of germ cell tumor.Recent research demonstrated that octamer-binding transcription factor 4 (OCT4),sal-like gene 4 (SALL4) can be used as new germ cell tumor markers.This paper reviewed the research progress on the OCT4 and SALL4 in recent years,to provide the reference about the early diagnosis,tumor typing,condition estimation,prognosis and targeted therapy of germ cell tumors.