Intestinal Amyloidosis with Intractable Diarrhea and Intestinal Pseudo-obstruction.
10.4166/kjg.2012.60.3.172
- Author:
Yeon Joo KIM
1
;
Hyun Soo KIM
;
Seon Young PARK
;
Sang Woo PARK
;
Yoo Duk CHOI
;
Chang Hwan PARK
;
Sung Kyu CHOI
;
Jong Sun REW
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. dshskim@jnu.ac.kr
- Publication Type:Case Reports
- Keywords:
Amyloidosis;
Diarrhea;
Intestinal pseudo-obstruction
- MeSH:
Administration, Oral;
Adult;
Amyloidosis/complications/*diagnosis/drug therapy;
Anti-Inflammatory Agents/therapeutic use;
Colchicine/therapeutic use;
Colonoscopy;
Diarrhea/*etiology;
Female;
Humans;
Intestinal Mucosa/pathology;
Intestinal Pseudo-Obstruction/*diagnosis/etiology;
Prednisolone/therapeutic use;
Serum Amyloid A Protein/metabolism;
Tomography, X-Ray Computed;
Tubulin Modulators/therapeutic use
- From:The Korean Journal of Gastroenterology
2012;60(3):172-176
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report herein a case of intestinal amyloidosis with grave prognosis that caused intractable diarrhea and intestinal pseudo-obstruction, alternately in spite of intensive conservative treatment. A 44-year-old woman was admitted for fever, diarrhea, and crampy abdominal pain which had been continuned during 6 months. Abdomen CT scan showed edematous wall thickening of the small bowel and right colon, and colonoscopic biopsy revealed amyloid deposition in the mucosa. Monoclonal light chains in serum and/or urine were not detected and highly elevated serum amyloid A was shown. In spite of intensive treatment including oral prednisolone and colchicine, diarrhea and intestinal pseudo-obstruction developed alternately, general status rapidly got worsened and died after two months.
