A Case of Severe Acute Hepatitis A Complicated with Pure Red Cell Aplasia.
10.4166/kjg.2012.60.3.177
- Author:
Pyoung Suk LIM
1
;
In Hee KIM
;
Seong Hun KIM
;
Seung Ok LEE
;
Sang Wook KIM
Author Information
1. Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea. ihkimmd@jbnu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Hepatitis A;
Severe hepatitis;
Pure red-cell aplasia
- MeSH:
Acute Disease;
Acute Kidney Injury/etiology;
Adult;
Anti-Inflammatory Agents/therapeutic use;
Bone Marrow/pathology;
Female;
Hepatitis A/complications/*diagnosis;
Humans;
Prednisone/therapeutic use;
Red-Cell Aplasia, Pure/complications/*diagnosis/drug therapy
- From:The Korean Journal of Gastroenterology
2012;60(3):177-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatitis A is typically a self-limited acute illness that does not progress to chronic hepatitis. In rare cases, acute hepatitis A can be associated with serious complications (such as fulminant hepatitis or acute kidney injury) and may result in death or liver transplantation. Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood, and isolated erythroblastopenia with normal granulopoiesis and megakaryopoiesis in the bone marrow. PRCA is a rare hematopoietic complication of acute viral hepatitis, and few cases associated with hepatitis A virus infection have been reported. Recently, we experienced a case of severe hepatitis A complicated by fulminant hepatitis and acute kidney injury followed by PRCA which showed a favorable response to oral corticosteroids.
