Outcomes of adjuvant intravitreal anti-vascular endothelial growth factor therapy in advanced Coats disease
10.3760/cma.j.issn.1005-1015.2015.03.010
- VernacularTitle:玻璃体腔注射抗血管内皮生长因子药物联合其他方法治疗晚期Coats病的疗效观察
- Author:
Huan CHEN
;
Youxin CHEN
;
Ruoan HAN
- Publication Type:Journal Article
- Keywords:
Retinal telangiectasis/therapy;
Angiogenesis inhibitors/therapeutic use;
Antibodies,monoclonal/therapeutic use
- From:
Chinese Journal of Ocular Fundus Diseases
2015;31(3):252-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of adjuvant intravitreal injection of anti-vascular endothelial growth factor (VEGF) therapy for advanced Coats disease.Methods This study is a retrospective case series study.Fourteen patients (14 eyes),presenting Coats Stages 3B and 4 (8 and 6 eyes,respectively) were enrolled.All the patients were treated with adjuvant intravitreal anti-VEGF therapy.The intravitreal anti-VEGF injections varied from 1 to 7,with a median injections of 2.14.In 14 eyes,combined therapy was subretinal fluid drainage in 4 eyes,photocoagulation in 2 eyes,vitrectomy in 8 eyes.The follow-up period was ranged from 4 to 36 months,with a median follow-up of 18.8 months.Visual acuity and retinal reattachment were observed in follow up.Results At last follow up,global suvival was 100.0％ with no enucleation performed in any patient because of disease progression.Except for 2 children who were unable to cope with the visual acuity test,visual acuity was improved in 2 patients,stable in 8 patients,and decreased in 2 patients.5 patients (35.7％) achieved in complete retinal reattachment,3 patients (21.4％) were succeed in partial retinal reattachment,and the remain 6 patients(42.8％) failed in retinal reattachment.Two patients developed cataract after vitrectomy,and no other adverse reaction was observed during follow-up.Conclusion Anti-VEGF therapy combined with classic treatments in advanced Coats disease can keep or impove the visual acuity in most patients by reducing of subretinal exudation.
