Relationship between Tumor Necrosis Factor-α Gene Polymorphism and Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus
10.3969/j.issn.0253-9896.2010.02.005
- VernacularTitle:TNF-α基因多态性与2型糖尿病患者轻度认知功能障碍的相关性
- Author:
Fangfang SHEN
;
Yun XIE
;
Xia ZHAO
;
Xianhai MENG
;
Weilin WANG
;
Liping HAN
;
Xiuying QI
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type2;
tumor necrosis factor-alpha;
cognition disorders;
genes
- From:
Tianjin Medical Journal
2010;38(2):94-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between tumor necrosis factor-α (TNF-α)-308A/G gene polymorphism and mild cognitive impairment(MCI)in patients with type 2 diabetes mellitus(T2DM),and their correlative risk factors thereof.Methods:Forty cases of T2DM with MCI and 80 cases of T2DM without MCI were selected for this study.The polymorphism of the TNF-α-308A/G was detected by PCR-restriction fragment length polymorphism (PCR-RFLP).According to the clinical data,such as course of disease,plasma glucose,plasma fat and body mass index(BMI),the independent risk factors of T2DM and MCI were analyzed by non-conditional logistic regression.Results:The frequency of TNF-α2 allele was significantly higher in the group of T2DM with MCI than that without MCI (P＜0.01).The indexes of the statistical significant difference between the two groups were the age,course of disease,postprandial blood glucose(P2BG),glycosylated hemoglobin,body mass index,family history of T2DM,hypertension,diabetic retinopathy,diabetic peripheral neuropathy and TNF-α.The independent risk factors included TNF-α,diabetic peripheral neuropathy,diabetic retinopathy,age and P2BG.Conclusion:There is a significant relationship between TNF-α2 allele and T2DM with MCI.There is a significant relationship between the age,control of plasma glucose and microvaseular complication of T2DM with the cognitive funotion.
