Zinc finger protein A20 and dendritic cell
10.3760/cma.j.issn.1009-9921.2010.04.021
- VernacularTitle:锌指蛋白A20与树突状细胞
- Author:
Xiaoying ZHANG
;
Ying YAN
;
Haifeng SONG
;
Hu CHEN
- Publication Type:Journal Article
- Keywords:
Zinc finger protein A20;
Denclritic cell;
NF-κB
- From:
Journal of Leukemia & Lymphoma
2010;19(4):253-256
- CountryChina
- Language:Chinese
-
Abstract:
As a zinc finger protein with ubiquitin-modifying activity, A20 is highly expressed in most mammalian cell in response to stimuli of tumor necrosis factor (TNF), lnterleukin-1 (IL-1), lipopolysaccharide (LPS) and other factors. A20 has been found to play a crucial effect in control of the cell maturation, cytokine production and immunostimulatory potency of dendritic cells (DCs) via modulating down-regulation of NF-κB signaling transduction pathway. In this brief review, we descript the biological characteristics of A20 and the involvement of the A20 in the pathway of the immune responses toward to the DC cell maturation and immunostimulatory potency.
