Effect of ultrasound radiation force on microbubble contrast agents with different exposure parameters
- VernacularTitle:不同参数的超声辐射力对微泡造影剂的作用
- Author:
Jia LIU
;
Ping ZHANG
;
Zheng LIU
;
Yang ZHAO
;
Shunji GAO
;
Yuejuan GAO
;
Yunhua GAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography,interventional;
Microbubble;
Displacement;
Aggregation
- From:
Chinese Journal of Medical Imaging Technology
2010;26(2):225-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of microbubble (MB) contrast agents impacted by different parameters such as acoustic pressure, frequency, duration of exposure, and MB concentration under flowing condition. Methods A capillary flow mimic model was set up for observation and analysis of MB displacement and aggregation under stereomicroscope. Results The displacement and aggregation of ultrasonic occurred significantly at the frequency of 2.0 MHz than 1.0 MHz and 0.5 MHz. Under low acoustic pressure, MBs were not visually disrupted but the flow slowed down. The aggregation and deflection applying to MB was stronger in the tube happened at the MB concentration of 7×10~7/ml than 7×10~5/ml, but did not when the concentration rose to 7×10~9/ml because of the high viscosity. The ultrasound exposure time could not affect significantly in displacement and MB aggregation. Conclusion MB contrast agents can be manipulated under some ultrasound parameters. It is expected to be physically modulated in blood vessels, in order to increase targeted adhesions for many therapeutic purposes.
