Research progress of bone marrow-derived mesenchymal stem cells in blood diseases
10.3760/cma.j.issn.1009-9921.2010.01.024
- VernacularTitle:骨髓间充质干细胞在血液系统疾病中的研究进展
- Author:
Yun WANG
;
Rong TAO
;
Hui LIANG
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells;
Hematologic diseases
- From:
Journal of Leukemia & Lymphoma
2010;19(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells (MSC) are the non-hematopoietic cellular component in the bone marrow that have multiple differentiation potency. MSC play a key role in the regulation of bone marrow hematopoietic niche and modulation of immune function through various mechanisms. They are currently recognized as a promising cell source in tissue engineering, a vehicle in gene therapy and a powerful tool in the management of graft-versus-host disease after allogeneic stem cell transplantation. In this review some momentous aspects regarding the current status and potential clinical applications of MSC in hematopoietic stem cell transplantation, aplastic anemia and multiple myeloma were summarized.