Research progress of bone marrow-derived mesenchymal stem cells in blood diseases

VernacularTitle:骨髓间充质干细胞在血液系统疾病中的研究进展
Author: Yun WANG ; Rong TAO ; Hui LIANG
Publication Type:Journal Article
Keywords: Mesenchymal stem cells; Hematologic diseases
From: Journal of Leukemia & Lymphoma 2010;19(1):58-61
CountryChina
Language:Chinese
Abstract: Bone marrow mesenchymal stem cells (MSC) are the non-hematopoietic cellular component in the bone marrow that have multiple differentiation potency. MSC play a key role in the regulation of bone marrow hematopoietic niche and modulation of immune function through various mechanisms. They are currently recognized as a promising cell source in tissue engineering, a vehicle in gene therapy and a powerful tool in the management of graft-versus-host disease after allogeneic stem cell transplantation. In this review some momentous aspects regarding the current status and potential clinical applications of MSC in hematopoietic stem cell transplantation, aplastic anemia and multiple myeloma were summarized.