Clinical significance of p170, bcl-2, MRP by flow cytometry in acute leukemia
10.3760/cma.j.issn.1009-9921.2008.02.009
- VernacularTitle:流式细胞术检测急性白血病P-糖蛋白、多药耐药相关蛋白及bcl-2的临床意义
- Author:
Yang QIU
;
Yuejian LIU
;
Li GUO
;
Lujuan SHAN
;
Huishu GUO
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphocytic,acute;
Leukemia,non lymphocytic,acute;
Multidrug resistance;
P-170 glycoprotein;
Multidrug-resistance associated protein (MRP);
bcl-2 associated protein
- From:
Journal of Leukemia & Lymphoma
2008;17(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of p170, MRP, bcl-2 in clinical drug- resistance and their correlation. Methods There are 44 acute leukemia(AL) patients, among them ANLL is 29, ALL is 15.The expression of p170, MRP, bcl-2 were detected. At last, the patients were divided into two groups: CR and NR according to efficacy after two periods standard chemotherapy. Results Overexpression of p170, MRP,bcl-2 were found in AL (P ＜0.05). The expression of p170 and MRP were lower in CR group than that in NR groups in AML and ALL; there were 22 of 24 patients expressed one or two proteins in NR groups and the expression of p170 in patients was concordant with that of MRP to certain extent (P ＜0.01). The overexpression of bcl-2 was related with the worse prognosis. The expression of bcl-2 was lower significantly in CR group than in CR and NR (P＜0.05). Conclusion p170, bcl-2, MRP are all associated with clinical MDR. High expression of these proteins is an unfavorable factor to prognosis. The expression of MRP and p170 showed coincidence, but showed no significance with expression of bcl-2 in untreated patients, it indicated that the drug-resistance mediated by p170 was different from bcl-2.
