Significance of Cyclin D1 and bcl-2 expression in the diagnosis of B cell lymphoma
10.3760/cma.j.issn.1009-9921.2011.08.021
- VernacularTitle:Cyclin D1和bcl-2在B细胞淋巴瘤中的表达及其在鉴别诊断中的意义
- Author:
Qianqian YU
- Publication Type:Journal Article
- Keywords:
Lymphoma,B-cell;
Cyclin D1;
bcl-2
- From:
Journal of Leukemia & Lymphoma
2011;20(8):507-509
- CountryChina
- Language:Chinese
-
Abstract:
Based on the immunophenotype, B cell lymphoma can be distinguished into different isoforms, which have different incursions. Cyclin D1 has been detected in a wide variety of lymphoid and myeloid malignancies, which expression in B-cell tumors on an expanded group of lymphomas that included MCL, B-CLL, diffuse large B-cell lymphomas (DLBCL), marginal zone lymphoma (MZL), reactive hyperplasia group. Bcl-2 itself is highly expressed in the majority of B-cell lymphomas [follicular lymphoma (FL), DLBCL].Both of them play an important role in differential diagnosis of B cell lymphoma. So its sensitivity and specificity of test facility have crucial clinical value.
